The quarterback combo of Jake Waters and Daniel Sams combined to throw for 221 yards and run for 89 yards as the Wildcats (4-4, 2-3) beat the Cyclones for the sixth straight time.
Iowa State (1-7, 0-5) didn’t score until the Wildcats’ Robert Rose coughed up the ball at his own 10-yard line in the closing minutes, and DeVondrick Nealy took a toss-sweep for a touchdown.
That was the only time the Cyclones ran a play in the Wildcats’ red zone.
Grant Rohach threw for 88 yards for the Cyclones in place of Sam Richardson, who left midway through the second quarter. Richardson had been dealing with a lingering ankle injury.